Intravascular brachytherapy vs. drug-coated balloons for in-stent restenosis in patients with diabetes.

ABSTRACT:

Background

Patients who have diabetes mellitus experience significantly higher rates of in-stent restenosis following percutaneous coronary intervention compared to the general population. The underlying pathophysiology of restenosis is exacerbated by diabetes-specific mechanisms including endothelial dysfunction, enhanced inflammatory response, and accelerated smooth muscle cell proliferation. While both intravascular brachytherapy (IVB) and drug-coated balloons (DCB) have been used to treat this condition, their comparative effectiveness in this high-risk population has never been evaluated in a long-term study.

Objectives

To compare the efficacy and safety of IVB vs. DCB for the treatment of in-stent restenosis specifically in patients with diabetes.

Methods

This d

SUBMITTER: Sella G 

PROVIDER: S-EPMC12832873 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature