Colistin-based combination therapy versus monotherapy for carbapenem-resistant gram-negative bacterial infections: a systematic review and meta-analysis.

ABSTRACT:

Objective

The objective of this study was to summarize available data on colistin (COL) combination therapy or monotherapy for carbapenem-resistant gram-negative bacteria (CR-GNB).

Methods

Two reviewers independently evaluated and extracted data from PubMed, Embase, and Cochrane Library from inception to January 31, 2025, for studies comparing COL combination therapy with monotherapy in patients with CR-GNB infections. The primary outcome was all-cause mortality, and secondary outcomes included microbiological eradication rate, clinical improvement rate, length of stay (LOS), nephrotoxicity, and neurotoxicity. Differences for dichotomous outcomes were expressed as risk ratios (RRs) with 95% confidence intervals (CIs), whereas those for continuous outcomes were expressed as m

SUBMITTER: Yang T 

PROVIDER: S-EPMC12832914 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature