PD-L1 expression and mismatch repair deficiency in locally advanced head and neck squamous cell carcinoma treated with chemoradiotherapy: association with treatment response and survival.

ABSTRACT:

Background

Concurrent chemoradiotherapy (CCRT) served as the cornerstone of definitive treatment for locally advanced head and neck squamous cell carcinoma (LA-HNSCC), yet there was heterogeneity in patients' treatment responses. This study aimed to evaluate the clinical significance of programmed death ligand-1 (PD-L1) expression and deficient mismatch repair (dMMR) as predictive markers of response to CCRT in patients with LA-HNSCC.

Methods

This study retrospectively analyzed 156 cases of LA-HNSCC patients who received CCRT treatment at our hospital from January 2020 to April 2024. All patients received intensity-modulated radiotherapy with concurrent chemotherapy. PD-L1 expression was assessed using immunohistochemistry and quantified with the Combined Positive Score (CPS

SUBMITTER: Zhang B 

PROVIDER: S-EPMC12832915 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature