Impact of multidomain lifestyle intervention on dynamics of cognitive frailty: post hoc analysis of the FINGER trial.

ABSTRACT:

Background

Cognitive frailty (CF), a condition with physical frailty and mild cognitive impairment (MCI) without dementia, is potentially reversible and linked to adverse outcomes. We aimed to investigate the impact of a multidomain lifestyle intervention on temporal dynamics of CF in older adults at risk of dementia.

Methods

In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), 1259 participants, aged 60-77, were randomized to a 2-year multidomain lifestyle intervention or standard health advice. Frailty was defined by the modified Fried phenotype, and MCI by the lowest quintile in the neuropsychological test battery z score. Having pre-frailty/frailty and MCI was classified as CF. Transition probabilities and predictiveness of

SUBMITTER: Poyhonen J 

PROVIDER: S-EPMC12832955 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature