Curcumin for the clinical treatment of rheumatoid arthritis: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.

ABSTRACT:

Background

The efficacy and safety of curcumin in the treatment of rheumatoid arthritis (RA) remain controversial. We therefore conducted a meta-analysis to evaluate the efficacy and safety of curcumin in RA.

Methods

We searched PubMed, Embase, the Cochrane Library and Web of Science for relevant literature published up to July 30, 2025. The Cochrane risk of bias tool was used to assess bias in the included trials, and the Grade of Recommendations Assessment, Development and Evaluation (GRADE) framework was applied to evaluate the certainty of evidence. Meta-analyses were performed using Review Manager 5.3.

Results

Six studies involving 244 participants were included. The meta-analysis showed that curcumin significantly improved the following outcomes: American Colleg

SUBMITTER: Fan Y 

PROVIDER: S-EPMC12832973 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature