Low IgE and absence of sensitization in non-T2 asthma: a transcriptomic and cytokine study.

ABSTRACT:

Background

Asthma exhibits heterogeneity, including type 2 (T2-high) and non-T2 phenotypes. This study aimed to elucidate the inflammatory mechanisms that drive non-type 2 asthma, a subtype characterized by low immunoglobulin E levels and negative allergic sensitization. This context considers the complex processes of allergic sensitization.

Methods

We performed gene expression analysis in non-T2 (n = 11) versus T2-high (n = 17) pediatric patients using public datasets GSE145505 for comparison (non-atopic and high-atopic datasets). We applied Ingenuity Pathway Analysis (IPA) to identify canonical pathways. We used the Database for Annotation, Visualization, and Integrated Discovery (DAVID) for functional annotation. We examined the Reactome pathway activities, focusing on di

SUBMITTER: Lee JH 

PROVIDER: S-EPMC12832990 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature