Insomnia treatment based on the regulation of the GABAergic system: traditional Chinese medicine perspectives and therapeutic approaches.

ABSTRACT: Insomnia is a common clinical manifestation of central nervous system (CNS) dysfunction that may be attributable to the involvement of abnormalities in multiple systems. Dysfunction of the gamma-aminobutyric acid (GABA) system is one of the key pathologic factors responsible for the increased neural excitability. GABA has been regarded as the major inhibitory neurotransmitter in the CNS, which can maintain the dynamic balance of neural networks by regulating neuronal excitability. Traditional Chinese medicine (TCM), with its multi-component, multi-target therapeutic advantages, shows unique potential in regulating the GABAergic system to improve sleep disorders. Accordingly, this review systematically elucidated the underlying mechanisms of TCM in treating insomnia by regulating the GABAer

SUBMITTER: Cheng CZ 

PROVIDER: S-EPMC12833008 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature