Network pharmacology-based identification of potential drug targets and bioactive compounds in Lycii Fructus (Gouqizi) for the therapeutics of Parkinson's disease.

ABSTRACT:

Introduction

Parkinson's disease (PD) is a common neurodegenerative disease characterized by the loss of dopaminergic neurons without any curable treatment. Various traditional Chinese medicines have been employed to manage the progression of PD. Lycii Fructus has demonstrated promising therapeutic potential in neurological disorders; however, the exact molecular mechanisms and specific bioactive compounds responsible for its effects remain unclear. The current study investigates the potential targets and binding potential of Lycii Fructus compounds against PD using bioinformatics approaches.

Methods

Common disease and drug targets were retrieved and analyzed using protein-protein interactions and Cytoscape networks. Gene ontology enrichment analyses and KEGG p

SUBMITTER: Al Hashmi S 

PROVIDER: S-EPMC12833033 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature