Clinical characteristics and outcomes in 50 children with autoimmune hepatitis: a retrospective study from a single centre in China.

ABSTRACT:

Objectives

Little is known about autoimmune hepatitis (AIH) in Chinese children. The study aimed to explore the clinical characteristics and predictors of outcomes in the Chinese paediatric AIH cohort.

Methods

A retrospective review of all paediatric AIH cases from 2015 to 2025 was conducted at a single centre in Beijing, China.

Results

Of the 50 enrolled cases, 39 (78.0%) presented with type 1 AIH (consisting of 30 female children (60.0%); median age of 9.2 years). At presentation, 24 (48.0%) patients had cirrhosis, 11 (22.0%) had liver failure, and 10 (20.0%) had decompensated cirrhosis at presentation. Compared to type 1, children with type 2 were younger and had higher levels of serum alanine aminotransferase [270.0 (166.0, 599.0) U/L vs. 610.0 (510.0, 1231.0) U/L

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12833044 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature