Voxel-based morphometry and functional connectivity changes are associated with cognitive function in herpes simplex virus encephalitis.

ABSTRACT:

Purpose

Herpes simplex encephalitis (HSE) is a severe neurological condition associated with significant cognitive impairment and structural brain changes. This study aimed to investigate microstructural and functional connectivity (FC) alterations in HSE patients and their association with cognitive function, cerebrospinal fluid (CSF) parameters, and inflammatory markers.

Methods

A single-center cohort study was conducted with 73 HSE patients and 76 cognitively unimpaired controls. Voxel-based morphometry (VBM) and resting-state functional MRI (rs-fMRI) were used to assess VBM grey matter volume (GMV) and FC. Cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA). CSF pressure, protein levels, and proinflammatory cytokines (IL-6, IL-1β, IL-2, IL-4,

SUBMITTER: Feng Q 

PROVIDER: S-EPMC12833072 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature