Association of medication regimen complexity index with ADRs in HIV/AIDS patients: a retrospective cohort study.

ABSTRACT:

Purpose

To investigate the correlation between the medication regimen complexity index (MRCI) and adverse drug reactions (ADRs) among acquired immunodeficiency syndrome (AIDS) patients in the Chinese population.

Introduction

The complexity of antiretroviral therapy (ART) regimens in individuals living with human immunodeficiency virus (HIV) presents significant challenges to medication management. To date, no studies have investigated the correlation between the MRCI and ADRs.

Methods

This study retrospectively enrolled 1,010 patients. The MRCI was utilized to quantify the complexity of pharmacological treatment regimens. All suspected ADRs were assessed for causality using the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) system. Univariate and multiv

SUBMITTER: Sun J 

PROVIDER: S-EPMC12833075 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature