Long-term fate of long QT syndrome patients diagnosed in childhood and differential effects of beta-blockers.

ABSTRACT:

Background and aims

Congenital long QT syndrome (LQTS) is associated with the risk of major arrhythmic events (MAEs), which can be modified by beta-blocker (BB) administration. We aimed to evaluate the effects of selective vs. non-selective BBs on the cumulative burden of MAEs by performing a retrospective analysis of a cohort of LQTS patients diagnosed during childhood.

Methods

All pediatric patients (N = 179, female 54.7%) without structural heart disease diagnosed with LQTS (Schwartz score ≥3.5 points and/or presence of a pathogenic or likely pathogenic genetic variant) between 1985 and 2022, with a median presentation age of 10.8 and a median follow-up of 8.5 years, were included. Data were obtained from medical records, structured patient phone calls, and the Nat

SUBMITTER: Tavacova T 

PROVIDER: S-EPMC12833094 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature