The association between hypoglycemia and panvascular disease in type 2 diabetes patients: The correlation structure mediated by inflammatory and metabolic abnormalities.

ABSTRACT: BackgroundHypoglycemia in type 2 diabetes patients is associated with metabolic abnormalities and inflammation that affect vascular beds. The relationship between hypoglycemia and panvascular disease (PVD) is not clear. This study aimed to investigate the association between PVD and hypoglycemia, and to identify potential mediators.MethodThis retrospective cross-sectional study enrolled Patients from two centers in Chongqing China, and the results were further validated using UK Biobank data. Logistic regression was used to test the association of hypoglycemia and PVD. Stratification and interaction analyses to test the effects across study subgroups. Forward (hypoglycemia to PVD) and reverse (PVD to hypoglycemia) relationships were analyzed by structural equation modeling (SEM), which inc

SUBMITTER: Lan R 

PROVIDER: S-EPMC12833110 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature