Efficacy and safety of anticoagulant therapy in sepsis: A systematic review and meta-analysis.

ABSTRACT: ImportanceThe role of anticoagulant therapy as an adjuvant treatment for sepsis remains controversial. Although observational studies have often suggested benefits, large-scale randomized controlled trials have yielded conflicting results, and the risk-to-benefit profile across different anticoagulant agents remains unclear.ObjectiveTo evaluate the efficacy and safety of anticoagulant therapy and its effect on all-cause mortality and major bleeding events in adult patients with sepsis as well as explore differences between study designs and anticoagulant types.Data sources: A systematic search was conducted in PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science databases from inception to 7 August 2025.Study selection: Randomized contr

SUBMITTER: Lu J 

PROVIDER: S-EPMC12833118 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature