Exploring frequency-dependent and dynamic changes in brain connectivity of chronic back pain patients using degree centrality analysis.

ABSTRACT:

Background

Chronic Back Pain (CBP) may lead to a reorganization of brain function, which can be observed through the indicator of degree centrality (DC). Traditional pain research has predominantly focused on static measurements of brain function within classical frequency bands, which may not fully capture the complexities of chronic pain. This study not only employed static frequency division but also incorporated dynamic analyses to capture the evolving nature of brain activity in chronic pain conditions.

Methods

This study included a total of 31 patients with CBP and 33 age- and gender-matched healthy controls. Spontaneous brain activity was investigated by traditional DC, DC in subfrequency bands (slow-5, slow-4) and dynamic DC (dDC). Differences in brain regions betwee

SUBMITTER: Hu H 

PROVIDER: S-EPMC12833176 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature