Necrotising enterocolitis biomarkers: a systematic review.

ABSTRACT:

Background

Necrotising enterocolitis (NEC) is a severe acute inflammatory condition of the gastrointestinal tract that predominantly affects preterm neonates. The variable and often nonspecific clinical signs, followed by rapid progression into fulminant disease, and the lack of standardised definitions and biomarkers, make this condition notoriously difficult to diagnose. This systematic review aims to outline the inflammatory pathways involved in the pathogenesis of NEC and to identify potential biomarkers associated with the initial stages of disease progression.

Methods

Following the PRISMA guidelines, we conducted an electronic search of the available literature using the PubMed, Embase, and Cochrane electronic databases with the following search terms ("necrotizing ent

SUBMITTER: Faizan MA 

PROVIDER: S-EPMC12833235 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature