Tumor-derived extracellular vesicles mediate cell-specific uptake and facilitate enhanced doxorubicin delivery in breast cancer.

ABSTRACT:

Background

Chemotherapy suppresses tumor growth and metastasis, but its efficacy is limited by non-specificity, systemic toxicity, poor accumulation and side effects. Extracellular vesicles (EVs) derived from cells have recently been tested for carrying drugs due to their biocompatibility, stability, and ability to cross biological barriers. We aimed to investigate the potential of drug incorporation to breast cancer (BC) cells-derived EVs and their targeted cell-specific delivery.

Methods

EVs were isolated from MDA-MB-231 and MCF7 cells and characterized by nanoparticle tracking analysis and scanning electron microscopy. The cellular uptake of EVs assessed by PKH67 labelling and fluorescent microscopy. Doxorubicin (dox) was incorporated into EVs by sonication, entrapment wa

SUBMITTER: Alagundagi DB 

PROVIDER: S-EPMC12833375 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature