Cinnamomum verum extract as a potential therapeutic for atopic dermatitis through reducing lipid peroxidation and oxidative stress.

ABSTRACT:

Background

Oxidative stress and lipid peroxidation play crucial roles in the pathogenesis of atopic dermatitis (AD). Among the by-products of lipid peroxidation, 4-hydroxynonenal (4-HNE) is known to exacerbate inflammatory responses.

Methods

This study investigated the potential of Cinnamomum verum J. Presl. [Lauraceae] extract (CVE) in mitigating oxidative stress and suppressing 4-HNE-mediated inflammatory pathways in an AD model. The antioxidant properties of CVE were evaluated through lipid peroxidation assays, reactive oxygen species (ROS) measurement, and cytokine profiling.

Results

CVE treatment significantly reduced 4-HNE levels, decreased pro-inflammatory cytokine expression, and restored antioxidant enzyme activity.

Conclusion

These findings sug

SUBMITTER: Kim MJ 

PROVIDER: S-EPMC12833377 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature