Targeting the plasticity of intestinal neutrophils: bidirectional regulation strategies by natural products.

ABSTRACT: Historically, neutrophils have been regarded primarily as pro-inflammatory cells, yet recent advancements have revealed their phenotypic heterogeneity and functional plasticity with versatile immunophenotypes. Distinct subpopulations of neutrophils exhibit a functional duality, not only initiating and amplifying inflammation, but also actively promoting tissue restoration in diseases, such as inflammatory bowel disease (IBD), colorectal cancer (CRC) and intestinal infections. They contribute to the formation of a dynamic immune microenvironment in concert with the intestinal microbiota, epithelial cells, and other immune cell types. Current first-line therapies for enteric diseases often lack precision in modulating neutrophil functions. In contrast, natural products including alkaloids, p

SUBMITTER: Kang R 

PROVIDER: S-EPMC12833395 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature