Omaveloxolone promotes functional recovery of spinal cord injury by reducing inflammatory response and regulating macrophage polarization.

ABSTRACT:

Background

Spinal Cord Injury (SCI) is a severe central nervous system disorder that initiates inflammatory reactions, exacerbating tissue damage and impeding neuronal repair. Macrophage polarization plays a critical role in this pathological process: it significantly regulates inflammation resolution and tissue regeneration, rendering its modulation a key strategy for SCI repair. Omaveloxolone (Omav), a novel Nrf2 activator, has demonstrated potential in regulating inflammatory responses, suggesting it may serve as a promising candidate for SCI intervention.

Methods

To evaluate the efficacy and underlying mechanism of Omav in SCI repair, a spinal cord contusion model was established in animal subjects. Additionally, an in vitro lipopolysaccharide (LPS)-induced macrop

SUBMITTER: Zhao P 

PROVIDER: S-EPMC12833412 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature