Association between Body Roundness Index and diastolic function in middle-aged and older adults: a cross-sectional study.

ABSTRACT:

Background

Diastolic dysfunction (DD) represents an early indicator of cardiac impairment and is strongly linked to adverse cardiovascular outcomes. While obesity-related indices have been associated with DD, the role of Body Roundness Index (BRI)-a novel adiposity measure reflecting body shape-remains unclear. This study aimed to evaluate the association between BRI and diastolic function in a community-based cohort.

Methods

This cross-sectional analysis included 1,466 participants from the Longitudinal Investigation of Osteoarthritis and Cardiovascular Health Status cohort. BRI was calculated using a validated formula, and DD was assessed via echocardiographic parameters. BRI's optimal cutoff was derived via 1000-iteration bootstrap ROC analysis. Multivariable regression m

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12833456 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature