Comparative evaluation of the effectiveness of a novel composite bone substitute synthesized from eggshell-derived hydroxyapatite and fish collagen in bone regeneration of critical-sized calvarial defects in Wistar rats.

ABSTRACT:

Background

Large bone deformities pose significant challenges in regenerative periodontal surgeries. A healthy underlying bone and the osteoinductive effect of the surrounding environment are the primary factors that influence bone regeneration. Collagen and hydroxyapatite are universally used bone substitutes owing to their excellent biocompatibility and biodegradability. Innovations in the osteoinductive properties of hydroxyapatite and its use in different modified forms, combining it with other materials, may result in enhanced biomechanical properties. This research utilized domestic chicken eggshells to synthesize hydroxyapatite and fish scales to extract collagen. The novel composite graft was prepared by integrating both materials. The beneficial effects of the composite gr

SUBMITTER: Prathap S 

PROVIDER: S-EPMC12833466 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature