Association of Hypoxic Burden With Cardiovascular Events: A Risk Stratification Analysis of the Randomized Intervention With CPAP in Coronary Artery Disease and Sleep Apnea Cohort.

ABSTRACT:

Background

The apnea-hypopnea index (AHI), the standard measure of OSA, has limitations in reflecting disease severity.

Research question

Is high hypoxic burden (HB) more strongly associated with major cardiovascular and cerebrovascular adverse events (MACCEs) than AHI of ≥ 30 events/h?

Study design and methods

This secondary analysis of the Randomized Intervention With CPAP in Coronary Artery Disease and Sleep Apnea observational cohort included 368 adults with OSA (AHI ≥ 15 events/h) with (n = 155) and without (n = 244) excessive daytime sleepiness (EDS), defined as an Epworth Sleepiness Scale score of ≥ 10. HB was calculated as the total area under respiratory event-related desaturations divided by total sleep time. Patients were classified as having high or low HB

SUBMITTER: Peker Y 

PROVIDER: S-EPMC12833478 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature