Low-Tidal-Volume Ventilation and Mortality in Patients With Acute Brain Injury: A Secondary Analysis of an International Observational Study.

ABSTRACT:

Background

Low-tidal-volume ventilation (LTVV) improves outcomes in critically ill patients, but its impact in patients with acute brain injuries (ABIs) is less certain.

Research question

What is the association between LTVV and mortality in mechanically ventilated patients with ABI?

Study design and methods

We did a secondary analysis of a prospective observational study (NCT03400904; https://clinicaltrials.gov/study/NCT03400904). We compared LTVV (≤ 8 mL/kg predicted body weight [PBW]) with tidal volumes > 8 mL/kg PBW over the first 7 days of mechanical ventilation. Alternate analyses used lower thresholds for LTVV. Marginal structural Cox models were used to evaluate the association between LTVV and ICU mortality up to 60 days. Stabilized inverse probability treatm

SUBMITTER: Daza JF 

PROVIDER: S-EPMC12833485 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature