Blood-Based Lead Biomarkers and Sarcopenia Indicators in Older Adults.

ABSTRACT:

Background

Chronic exposure to low levels of lead (Pb) remains a widespread public health issue, especially among older adults. While its neurotoxic and cardiovascular effects are well recognized, its potential role in accelerating age-related musculoskeletal decline is less understood. Emerging evidence suggests Pb may contribute to sarcopenia, but epidemiological data, especially regarding the most informative biomarkers of exposure, are limited.

Methods

We analysed data from 11 842 participants aged ≥ 60 years across four population-based studies (NHANES III, NHANES 1999-2006, NHANES 2011-2012 and Seniors-ENRICA-2). Sarcopenia indicators included muscle strength (grip strength and chair stand test), muscle mass (dual-energy X-ray absorptiometry, calf circumference and arm

SUBMITTER: Koni A 

PROVIDER: S-EPMC12833499 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature