Fibre Type-Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resistance Training and Beta₂-Adrenergic Agonist.

ABSTRACT:

Background

Skeletal muscle is essential for metabolic health and physical function. While resistance training promotes muscle hypertrophy, alternative therapeutic strategies are needed for individuals unable to engage in physical activity. Because beta₂-adrenergic stimulation induces muscle growth without mechanical load, we assessed muscle fibre type-specific proteomic adaptations to prolonged beta₂-adrenergic stimulation and resistance training to decipher shared and distinct remodelling patterns.

Methods

We collected vastus lateralis biopsies from 21 moderately trained young males (mean ± SD, age: 24 ± 3) before and after 4-week whole-body resistance training (three sessions/week) or daily inhalation of beta₂-adrenergic agonist terbutaline

SUBMITTER: Jessen S 

PROVIDER: S-EPMC12833500 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature