Beyond the hippocampus: Limbic white matter injury implicated in post-radiation memory performance in primary brain tumor patients.

ABSTRACT:

Background

Limbic white matter (WM) of the Papez circuit, including the fornix, dorsal cingulum, and parahippocampal cingulum (PHC), interplay with the hippocampus as key components of the memory network. We analyzed biomarkers of injury to these pathways to understand their impact on post-radiation therapy (RT) memory performance.

Methods

Primary brain tumor patients on a prospective trial receiving fractionated brain RT (n = 57) underwent volumetric MRI, diffusion tensor imaging, and memory assessments (Hopkins Verbal Learning Test-Revised [HVLT-R] Total and Delayed Recall and Brief Visuospatial Memory Test -Revised [BVMT-R] Total and Delayed Recall) at baseline and 3, 6, and 12 months post-RT. MRI biomarkers included volume, fractional anisotropy (FA), and mean diffusivit

SUBMITTER: Qian AS 

PROVIDER: S-EPMC12833530 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature