Optimization, thermo-oxidative stability, and biological activities of vitamin E-chitosan-TPP nanoformulations.

ABSTRACT: Enhancing stability is a crucial factor in selecting bioactive compounds in most applications, while encapsulation techniques have proven to be a promising solution. Despite the critical applications of α-tocopherol (α-TQ) in the food and pharmaceutical industries, it is easily degraded by heat and oxidized by various oxidants in cells and foods; therefore, its more stable but less active acetate form (α-TQA) is commonly utilized. This study first optimized the preparation of the chitosan (CS) α-TQ nanoemulsion (α-TQ/CS-TPP/NE) using response surface methodology (RSM), achieving a minimum particle size of 278.1 nm; nanoparticles were also prepared and characterized by IR, TEM, and thermal analysis. Second, the chitosan nanoformulation exhibited greater thermal and oxidative stability again

SUBMITTER: Ali HM 

PROVIDER: S-EPMC12833638 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature