PH-responsive hyaluronic acid-co-poly(acrylic acid) hydrogel scaffolds for modified release of mesalamine; characterization and biosafety evaluation.

ABSTRACT: The current study focuses on the development of pH-sensitive hydrogels for the controlled release of mesalamine at a specific pH. A free radical polymerization technique was used, and the formulated hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis, scanning electron microscopy, swelling and drug release studies. FTIR confirmed the successful formation of a polymeric network with efficient incorporation of the drug. TGA revealed that the hydrogel demonstrated significantly improved thermal stability compared to the unmodified polymer, with SEM images showing a rough surface with a notable porous structure. Swelling and drug release behaviors were assessed at 37 °C in buffer solutions simulating gastric (pH 1.2) and intestinal (pH 7.4

SUBMITTER: Liaqat H 

PROVIDER: S-EPMC12833727 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature