New diterpenoids and sesquiterpenoids from Siegesbeckia pubescens Makino and their anti-inflammatory activity.

ABSTRACT: Six undescribed terpenoids were isolated from the aboveground parts of Siegesbeckia pubescens Makino. These compounds include four diterpenoids (1-4) and two sesquiterpenoids (5-6), as well as thirteen known compounds (7-19). The structures of new compounds were determined through spectroscopic analysis, DP4+ Analysis and ECD calculation. The protective effect of all compounds against lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 cells was tested. The result showed that compounds 2-9, 12-15 and 17-19 significantly inhibited the production of nitric oxide (NO) in LPS-induced RAW 264.7 cells, among which compound 18 demonstrated the best inhibitory activity against NO release. The potential anti-inflammatory mechanism was investigated through molecular docking. The molecu

SUBMITTER: Qu L 

PROVIDER: S-EPMC12833915 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature