Traffic-related air pollution significantly aggravates the detrimental effect of infections on the risk of Alzheimer's disease and other dementias, especially in non-carriers of APOE4.

ABSTRACT: Alzheimer's disease (AD) is a complex neurodegenerative disorder influenced by various factors, including genetic and exposure-related. Certain combinations of these factors may promote AD more substantially than others. APOE4 is the strongest genetic risk factor for AD. Traffic-related air pollution (TRAP) and infections are important exposure-related AD risk factors. Here we investigated how the interplay between a history of infections and chronically high exposure to TRAP (highTRAP) impacts the subsequent risk of AD and other dementias (AD+) in carriers and non-carriers of APOE4 in UK Biobank (UKB) participants aged 60-75 years. HighTRAP was approximated by the proximity (50 meters or less) of a participant's primary residence to a major road. Chi-square, Wilson score interval, Wald in

SUBMITTER: Popov VA 

PROVIDER: S-EPMC12833968 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature