Genetically predicted immune cell-mediated causal associations between 473 gut microbiome species and neurodevelopmental disorders.

ABSTRACT:

Background

Neurodevelopmental disorders (NDD) are a class of complex diseases whose underlying pathogenesis has not been fully elucidated. Previous observational studies have reported that gut microbiota dysbiosis may be one of the potential risk factors for the development of NDD, however, causal relationships and the potential mediating role of immune cells have yet to be established.

Methods

Bidirectional two-sample Mendelian randomization (TSMR) and two-step Mendelian randomization (two-step MR) methods, mainly using inverse variance weighting (IVW), were used to explore the potential associations between gut microbiota and NDD, as well as the mediating role of immune cells in the causal pathway. Bayesian weighted Mendelian randomization (BWMR) method was additionally us

SUBMITTER: Yang H 

PROVIDER: S-EPMC12834023 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature