Brain-wide mapping of acute hypoxia-induced neuronal activation in mice: A c-Fos immunofluorescence study.

ABSTRACT: Acute hypobaric hypoxic exposure, defined as rapid ascent to high altitude with brief sojourn, triggers profound physiological adaptations while increasing risks of acute mountain sickness (e.g., gastrointestinal distress, pulmonary/cerebral edema). Beyond these somatic manifestations, cognitive deficits frequently emerge under hypoxic stress, yet the neural substrates mediating these impairments remain poorly mapped. To systematically characterize hypoxia-induced brain activation patterns, we conducted whole-brain mapping of neuronal activity changes in mice exposed to acute hypobaric hypoxia versus normoxic controls using c-Fos immunofluorescence, a robust marker of neuronal activation. Our functional analysis focused on key brain regions governing: cardiorespiratory homeostasis, attenti

SUBMITTER: Yu X 

PROVIDER: S-EPMC12834024 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature