Impaired touch sensation on hairy skin in HCN3-deficient mice.

ABSTRACT: The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel HCN3 is expressed in sensory dorsal root ganglia (DRG) neurons, but its contribution to somatosensory processing remains poorly understood. Here, using RNA in situ hybridization, we found that Hcn3 is widely expressed in various populations of DRG neurons. Analysis of HCN3-deficient mice in a series of behavioral tests for somatosensory function revealed that HCN3 deletion led to profound impairments in mechanical sensation on hairy skin. However, the mechanical sensation on glabrous skin and responses to noxious heat and cold stimuli were not affected in the absence of HCN3. Electrophysiological recordings revealed that deletion of HCN3 reduced the HCN current (I_h) density and affected the actio

SUBMITTER: Metzner K 

PROVIDER: S-EPMC12834049 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature