Acute gluten-induced inflammatory response highlights CCL20 as a potential biomarker for celiac disease.

ABSTRACT:

Background

Diagnosis of celiac disease (CD) remains challenging in individuals already on a gluten-free diet (GFD). Although several alternative methods have been proposed, they have limitations. Identifying inflammation-related proteins that rapidly respond to gluten exposure in blood may offer diagnostic alternatives. We aimed to characterize the inflammatory protein response to gluten in patients with CD on a GFD, and to assess the diagnostic potential of candidate biomarkers and their association with clinical symptoms.

Methods

Seventeen patients with CD and 15 non-CD individuals on a GFD (≥ 1 month) consumed 10 g of gluten. Serum, plasma and clinical symptoms were collected at baseline and 4 h post-gluten ingestion to assess changes in 92 inflammation-related proteins.

SUBMITTER: Gomez-Aguililla S 

PROVIDER: S-EPMC12834126 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature