Genomic characterization of <i>Actinobacillus pleuropneumoniae</i> serovars 5, 8, and 15 strains from diseased pigs in eastern Chinese provinces.

ABSTRACT: Actinobacillus pleuropneumoniae causes porcine infectious pleuropneumonia in pigs. We aimed to characterize the phenotypic and genomic features of three A. pleuropneumoniae strains from clinical cases in eastern Chinese provinces. The serovar 5 strain ZJNH2023 was more pathogenic than strains AH2020 and ZJXS2022 in a murine model and was resistant to multiple antimicrobials. The core genome SNP (single nucleotide polymorphism) tree indicates that the three isolates are clustered with serovars 5, 8, and 15 strains of archived genomes. They harbor plasmids conferring resistance to florfenicol and are of substantial genome diversity, having more prophages, genomic islands (GIs), and antimicrobial resistance genes (ARGs) than the strains of corresponding serovars from other studi

SUBMITTER: Li Y 

PROVIDER: S-EPMC12834162 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature