One-pot synthesis of ketones and symmetrical anhydrides from carboxylic acids.

ABSTRACT: A one-pot synthesis of ketones from carboxylic acids is presented, employing 2-nitrobenzenesulfonyl chloride as an activating reagent in the presence of organomagnesium or organolithium nucleophiles. Additionally, activation of the carboxylic acids with 2-nitrobenzenesulfonyl chloride enabled the formation of symmetrical anhydrides. Subsequent conversion of these anhydrides into the desired ketones also proceeded with good yields.

SUBMITTER: Roy S 

PROVIDER: S-EPMC12834245 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature