Regulation of infant gut microbiota and metabolic pathways by human milk oligosaccharides: a multi-omics investigation.

ABSTRACT: The third-most solid component in breast milk is human milk oligosaccharides (HMOs)-crucial for the growth and development of infants. HMOs are divided into three main categories: fucosylated, nonfucosylated, and sialylated HMOs. However, comparative studies evaluating the variations of the impact of in vitro fermentation of these typical or dominant HMOs on the metabolic functions of an infant's gut microbiome remain limited. Therefore, we systematically analyzed the role of three typical HMOs-2'-fucosyl lactose, lactose-N-tetrose, and 3'-sialyllactose-in the structural reshaping of the infant intestinal flora; we also explored their impact on short-chain fatty acid (SCFA) production and metabolism, as well as their overall metabolic spectrum. We found that HMOs aided the gr

SUBMITTER: Luo L 

PROVIDER: S-EPMC12834247 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature