Precision Medicine Program in Chinese Pediatric Patients With Sarcoma.

ABSTRACT:

Purpose

Molecular profiles of sarcomas in Chinese children remain unknown. The Chinese Pediatric Precision Oncology Group (CPPOG) is a prospective precision medicine program aimed at defining tumor molecular profiles in pediatric oncology patients across China, which aids diagnosis and treatment decisions. Herein, we report, to our knowledge, the first data from the CPPOG trial.

Methods

Panel sequencing (830-gene DNA panel and 395-gene RNA panel) was performed on 214 tumors from 210 patients with sarcoma from 11 centers, between April 2021 and January 2022 in China. This study was prospectively analyzed to characterize subtype-specific somatic alterations and pathways. Molecular features among subgroups concerning response to treatment and pathologic characteristics were als

SUBMITTER: Lu S 

PROVIDER: S-EPMC12834276 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature