TAK1 activates PANoptosis through the NF-κB signalling pathway to delay diabetic wound healing.

ABSTRACT:

Background

PANoptosis is a comprehensive form of cell death regulation that involves the interplay of pyroptosis, apoptosis, and necrosis. As a key regulator of PANoptosis, TAK1 plays a crucial role in multiple cell death pathways. However, its specific mechanism in the process of diabetic wound (DW) healing remains unclear. This study aimed to explore the role of TAK1 in regulating PANoptosis and its impact on DW healing.

Methods

We used immunofluorescence, TUNEL staining, and EthD-III staining to analyse the relationship between TAK1 activity and PANoptosis. RNA sequencing was used to investigate the regulatory role of TAK1 and the NF-κB pathway under high-glucose conditions. Additionally, molecular docking and coimmunoprecipitation experiments were performed to verify the

SUBMITTER: Wang X 

PROVIDER: S-EPMC12834300 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature