Biological Aging in Combination with Lifestyle Factors in the Blood-Based Methylome: A Biomarker for Colorectal Cancer Susceptibility in African American Women.

ABSTRACT: DNA methylation (DNAm)-based estimators of age are highly accurate for biological aging in multiple tissues, but their functional roles remain poorly understood in colorectal cancer (CRC), an age-related disease whose burden is higher in aged African Americans (AAs) than in whites. A greater rate of epigenetic age deviation from chronologic age was observed in AAs' colorectal tissues than in whites', emphasizing AA-specific investigation for epigenetic aging in CRC. Tumor tissue-based DNAm exclusively reflects cancerization, raising a question about its cancer predictability. A prediagnostic peripheral blood leukocyte (PBL)-based DNAm aging marker may thus provide keys to CRC etiology and prevention. From the largest study cohort, we examined 621 AA postmenopausal women 50-79 years old, in

SUBMITTER: Jung SY 

PROVIDER: S-EPMC12834397 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature