Clinicopathological Features of Superficial Non-Ampullary Duodenal Epithelial Tumors Involving Brunner's Glands.

ABSTRACT:

Background and aims

Although Brunner's glands (BGs), located in the submucosa of the duodenum, may be involved by tumor cells of superficial non-ampullary duodenal epithelial tumors (SNADETs), the detailed incidence and histopathological features have not yet been analyzed. This study aimed to clarify the histopathological relationship between SNADETs and BGs.

Methods

We retrospectively analyzed SNADETs that were resected at a single center between 2006 and 2021. Resected specimens were histologically evaluated to determine the presence and/or involvement of SNADET in BGs. The relationship between clinicopathological features and tumor involvement in BGs was also assessed.

Results

In total, 114 lesions were included. Direct connection with BGs was seen in 52.6% of SNA

SUBMITTER: Takayama K 

PROVIDER: S-EPMC12834701 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature