Peripheral Blood Skin-Homing T Cells Define Immunological Endotypes in Atopic Dermatitis: A Case-Control Study in a Mexican Population.

ABSTRACT:

Background and aims

Atopic dermatitis (AD) is a chronic inflammatory skin disease with marked immunological heterogeneity. T-cell subsets expressing CLA, CCR4, and CCR10 are involved in skin inflammation, but their frequency and expression patterns in AD remain poorly characterized. This study aimed to define distinct immunological endotypes of AD in the Mexican population by analyzing the frequency of CLA⁺ T cells expressing CCR4 and CCR10, along with their cytokine production profiles.

Methods

Flow cytometry quantified CD4⁺ and CD8⁺ T cells in 47 Mexican AD patients, 15 healthy controls, and 16 allergic individuals. Principal component analysis and unsupervised clustering were used to identify immunological patterns.

Results

Two AD endotypes were identified. Endotyp

SUBMITTER: Luis Carlos ZP 

PROVIDER: S-EPMC12834705 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature