Low EVI1 expression at diagnosis identifies a high-risk subgroup in adult Ph-negative B-cell acute lymphoblastic leukemia.

ABSTRACT:

Background

The prognostic impact of EVI1 expression in B-cell acute lymphoblastic leukemia (B-ALL) remains to be explored.

Method

Bone marrow (BM) samples collected from 436 consecutive newly diagnosed adult Ph-negative B-ALL patients were tested for EVI1 transcript levels using real-time quantitative PCR.

Result

The median EVI1 transcript level in the whole cohort was 0.40% (range: 0.0030-94.3%). Low EVI1 expression defined by lower three quartiles (EVI1 transcript levels was 2.3%) was significantly related to poorer relapse-free survival (RFS) and overall survival (OS) (p = 0.0010 and < 0.0001) and was an independent adverse prognostic factor for RFS (HR (95% confidence interval): 2.3 (1.2-4.1), p = 0.0070) and OS (HR

SUBMITTER: Kong S 

PROVIDER: S-EPMC12834734 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature