Glomerular hyperfiltration defined by eGFR and long-term clinical outcomes: a systematic review and meta-analysis.

ABSTRACT:

Background

Glomerular hyperfiltration (GHF) has been widely recognized as a potential risk factor. However, current evidence regarding both its precise definition and clinical prognostic value remains inconclusive.

Methods

We systematically searched PubMed, Embase, and the Cochrane Library, as well as reference lists of relevant articles. Cohort studies examining the association between eGFR-defined GHF and clinical outcomes were included, and meta-analyses were conducted using a random-effects model. Cross-sectional studies and data from the National Health and Nutrition Examination Survey (NHANES) were used to estimate and compare the 95th percentile of eGFR in healthy populations in China and the United States.

Results

The 95th percentile eGFR values among healthy

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12834743 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature