Alteration of brain metabolism in lacunar stroke based on ¹⁸F-FDG-PET/MRI analysis.

ABSTRACT:

Background and purpose

Lacunar stroke (LS) is caused by occlusion of the penetrating branches of the major cerebral arteries and includes small and deep infarcts. Our study aimed to explore brain metabolic alterations in LS.

Methods

Seventy individuals with LS (aged 53.89 ± 1.198 years, 52 males) and 70 healthy controls (HCs; aged 50.34 ± 0.737 years, 42 males) underwent brain 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging. Glucose uptake, metabolic connectivity, and metabolic networks at the group level were analyzed.

Results

Compared with HCs, LS patients exhibited a higher standardized uptake value in the right postcentral gyrus (p < 0.001) and lower metabolic connectivity between the right postcentral gyrus and the right caud

SUBMITTER: Huang RR 

PROVIDER: S-EPMC12834746 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature