Deciphering reprogramming efficiency in human induced pluripotent stem cells: insights from the generation of 150 cell lines.

ABSTRACT:

Introduction

The discovery of induced pluripotent stem cells (iPSCs) revolutionized the field of translational medicine by enabling the reprogramming of adult somatic cells into a pluripotent state. From personalized disease models to innovative cell therapies, iPSCs are poised to play a central role in the future of clinical medicine. iPSCs hold enormous promises due to their ability to self-renew indefinitely and differentiate into all somatic cell types, thus offering patient-specific cellular models and therapeutic options without the ethical constraints of embryonic stem cells (ESCs). iPSCs, which exhibit pluripotency similar to embryonic stem cells, are generated by introducing specific factors into terminally differentiated cells, inducing a shift in their epigenetic and tra

SUBMITTER: Kuebler B 

PROVIDER: S-EPMC12834790 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature