Tenecteplase in large-vessel occlusion with or without thrombectomy: a meta-analysis.

ABSTRACT:

Background

Despite the growing adoption of Tenecteplase for stroke thrombolysis, key questions such as the role of bridging therapy and extended-window use in large-vessel occlusion (LVO) patients with or without access to endovascular thrombectomy (EVT) remain unresolved.

Methods

We conducted a systematic review of randomized clinical trial (RCT) data involving LVO patients who were treated with or without Tenecteplase. Outcomes were stratified by EVT status, and further subgroup analysis based on treatment window (≤4.5 vs. > 4.5 h) was conducted. Generalized odds ratios (gORs) were used to assess disability reduction by modified Rankin Scale (mRS) shift analysis. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for functional independence (mRS 0-2), ex

SUBMITTER: Alkhiri A 

PROVIDER: S-EPMC12834819 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature