Hesperetin alleviates sepsis-associated acute respiratory distress syndrome via the PI3K/Akt/PTEN axis.

ABSTRACT: Sepsis-associated acute respiratory distress syndrome (ARDS) is a life-threatening condition marked by severe inflammation and oxidative stress, with limited therapeutic options. Hesperetin, a natural citrus flavonoid, has antioxidant and anti-inflammatory properties, but its molecular mechanisms in ARDS remain unclear. To explore the therapeutic potential and mechanisms of hesperetin in sepsis-associated ARDS using network pharmacology and in vitro experiments. Network pharmacology identified common targets of hesperetin and ARDS, followed by protein-protein interaction, Gene Ontology, and KEGG analyses to reveal hub targets and pathways. Molecular docking assessed binding affinities. In vitro, an LPS-induced MH-S alveolar macrophage model was used to evaluate hesperetin's effects on cyto

SUBMITTER: Ruan H 

PROVIDER: S-EPMC12835032 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature