SIRT3 attenuates AGEs-induced senescence in human granulosa cells through enhancing mitophagy.

ABSTRACT: Age-related decreases in follicle numbers and oocyte quality are major contributors to the decline in female fertility, which is associated with increased infertility rates. Emerging evidence suggests that targeting granulosa cell senescence could delay ovarian aging and depletion of the ovarian reserve, highlighting the potential for therapeutic interventions focused on granulosa cells. Advanced glycation end products (AGEs) accumulate with age and result in oxidative stress in the follicular microenvironment, but their direct impact on human granulosa cell (hGC) senescence and the fundamental processes are still mostly unknown. In this study, we found that AGEs treatment significantly exacerbated hGC senescence, impaired mitochondrial function, and suppressed mitophagy in a concentration

SUBMITTER: Li S 

PROVIDER: S-EPMC12835053 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature